Differential Tissue Expression of Three 35-kDa Annexin Calcium-dependent Phospholipid-binding Proteins
نویسندگان
چکیده
منابع مشابه
Differential tissue expression of three 35-kDa annexin calcium-dependent phospholipid-binding proteins.
We have purified three 35-kDa calcium- and phospholipid-binding proteins from rat liver. These three calcimedins bind to phosphatidylserine in a calcium-dependent manner and have been termed 35 alpha, 35 beta, and 35 gamma based on their relative charge as determined by isoelectric focusing. Purification of the three 35-kDa calcimedins is achieved by phenyl-Sepharose, ion exchange, and gel filt...
متن کاملAnnexin V, a calcium-dependent phospholipid-binding protein.
828 Introduction Calcium regulates cellular processes by interacting with calcium-binding proteins. Two major families of calcium-binding proteins have been identified: The E-F hand proteins, which include calmodulin, SlOO and calcyclin; and the annexins (see [ l ] for review, and [2] for annexin nomenclature). Both families constitute major pools of calcium-binding activity. They are found in ...
متن کاملCrystallization and preliminary X-ray studies of annexin IV (endonexin), a calcium-dependent phospholipid-binding protein.
Annexin IV (endonexin) has been purified from chicken liver and crystallized by the vapour diffusion method. Crystals which diffract to at least 2.2 A have been obtained. They belong to space group R3 and have unit cell dimensions of a = b = 99.4 A, c = 96.2 A, alpha = 90 degrees, beta = 90 degrees, gamma = 120 degrees. There is one molecule of 32,500 Da per asymmetric unit.
متن کاملCa2+-dependent and phospholipid-independent binding of annexin 2 and annexin 5.
Annexins are a family of homologous proteins that associate with anionic phospholipid (aPL) in the presence of Ca(2+). Evidence that the function of one annexin type may be regulated by another was recently reported in studies investigating cytomegalovirus-aPL interactions, where the fusogenic function of annexin 2 (A2) was attenuated by annexin 5 (A5). This observation suggested that A2 may bi...
متن کاملLocalization and structure of novel calcium-regulated phospholipid-binding proteins.
Greenberg, M. E. & Edelman, G. M. (1983) Cell 33. 767-779 Hexham. J. M., Totty. N. F., Waterfield, M. D. & Crumpton, M. J. (1986) Bioclwrn. Biophys. Res. Cornmun. 134, 248 -254 Huang. K. S., Wallner, B. P., Mattaliano, R. J., Tizard, R., Burne, L.. Frey, A,. Hession, C., McGray, P., Sinclair, L. K., Chow, E. P., Browning, J. L., Ramachandran, K. L.. Tang, J., Smart, J . E. & Pepinsky, R. B. (19...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)71701-8